Phospho-Nrf2 (Ser40) Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1609
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Phospho-Nrf2
(Ser40) Rabbit Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC, FC
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H
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90.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1,000-1:5,000
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1:10-1:50
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:100
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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Phospho-Nrf2
(Ser40) Rabbit Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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4780(Human)
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SwissProt
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Q16236(Human)
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Synonyms
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NRF2
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Category
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Metabolism
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Background
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The NF-E2 DNA
binding protein is composed of two subunits, p45 and MXYK. It regulates
expression of globin genes in developing erythroid cells through interaction
with MXY recognition elements (Mares). A family of NF-E2- related proteins,
which are collectively known as the Cap ‘n’ collar (CNC) family and include Nrf1 (also designated TCF11),
Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with MXY
proteins to bind Mare sequences. The Nrf proteins also bind the antioxidant
response element (ARE) and are implicated in the regulation of detoxification
enzymes and the oxidative stress response. They do so by heterodimerizing
with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression,
specifically the detoxifying enzyme NQO1. Nrf2 is widely expressed and is
thought to translocate to the nucleus XYter treatment with xenobiotics and
antioxidants, which stimulate its release from its repressor protein, Keap1.
The gene encoding human Nrf3 maps to chromosome 7p15.2. Nrf3 is highly
expressed in placenta, B cells and monocytes.
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包装清单:
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产品编号
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产品名称
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包装
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XY1609
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Phospho-Nrf2
(Ser40) Rabbit Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
Phospho-Nrf2
(Ser40) Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10