Phospho-JAK2 (Tyr1007/1008) Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1486
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Phospho-JAK2
(Tyr1007/1008) Rabbit Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC
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H, M, R
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130.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:500-1:1,000
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1:10-1:50
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1:50-1:200
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1:50-1:200
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1:50-1:200
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-
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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Phospho-JAK2
(Tyr1007/1008) Rabbit Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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3717(Human);
16452(Mouse); 24514(Rat)
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SwissProt
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O60674(Human);
Q62120(Mouse); Q62689(Rat)
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Synonyms
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JTK10; THCYT3
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Category
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Immunology/Inflamation
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Background
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JAK2 (Janus
Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine
kinases, which regulate a spectrum of cellular functions downstream of
activated cytokine receptors in the lympho-hematopoietic system.
Immuno-logical stimuli, such as interferons and cytokines, induce recruitment
of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then
phosphorylates proximal Stat factors, which subsequently dimerize,
translocate to the nucleus and bind to cis elements upstream of target gene
promoters to regulate transcription. The canonical JAK-Stat pathway is
integral to maintaining a normal immune system by stimulating proliferation,
differentiation, survival, and host resistance to pathogens. Altering
JAK-Stat signaling to reduce cytokine induced pro-inflammatory responses
represents an attractive target for anti-inflammatory therapies. Within the
JAK2 kinase domain, there is a region that has considerable sequence homology
to the regulatory region of the insulin receptor. Among a variety of sites,
Tyrosines 1007 and 1008 are sites of trans- or autophosphorylation in vivo
and in in vitro kinase reactions.
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包装清单:
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产品编号
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产品名称
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包装
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XY1486
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Phospho-JAK2
(Tyr1007/1008) Rabbit Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
Phospho-JAK2
(Tyr1007/1008) Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10