LDL Receptor Rabbit Monoclonal Antibody
|
产品编号
|
产品名称
|
产品包装
|
产品价格
|
|
XY1438
|
LDL Receptor
Rabbit Monoclonal Antibody
|
50μl
|
618.00元
|
|
来源
|
用途
|
交叉反应性
|
分子量
|
|
Rabbit
|
WB, IF, IHC,
ICC, FC
|
H, M
|
140.0kDa
|
WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
|
WB
|
IP
|
IF
|
IHC
|
ICC
|
FC
|
ELISA
|
ChIP
|
|
1:1,000-1:2,000
|
-
|
1:50-1:200
|
1:50-1:200
|
1:50-1:200
|
1:50-1:100
|
-
|
-
|
抗体详细信息如下:
|
About this
Antibody
|
|
Name
|
LDL Receptor
Rabbit Monoclonal Antibody
|
|
Category
|
Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
|
|
Isotype
|
IgG
|
|
Purification
|
XYfinity
purification
|
|
About the
Immunogen
|
|
Immunogen
|
Recombinant
protein
|
|
Gene ID
|
3949(Human);
16835(Mouse)
|
|
SwissProt
|
P01130(Human);
P35951(Mouse)
|
|
Synonyms
|
LDLR; Ldlr
|
|
Category
|
Metabolism
|
|
Background
|
LDLR (low
density lipoprotein receptor) is a member of the LDL receptor gene family,
which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family
is characterized by a cluster of cysteine-rich class A repeats, epidermal
growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain.
The LDL receptor is a cell surface transmembrane protein that mediates the
uptake of low density lipoprotein and its degradation in the lysosome, which
provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is
necessary for the receptor to cluster in coated pits, which promotes the
rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal
dominant disease, familial hypercholesterolemia (FH), which promotes
premature coronary atherosclerosis.
|
包装清单:
|
产品编号
|
产品名称
|
包装
|
|
XY1438
|
LDL Receptor
Rabbit Monoclonal Antibody
|
50μl
|
|
XY050
|
Western一抗稀释液
|
50ml
|
|
-
|
说明书
|
1份
|
保存条件:
LDL Receptor
Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10