PMS2 Rabbit Monoclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY1339
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PMS2 Rabbit
Monoclonal Antibody
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50μl
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618.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IP, IF,
IHC, ICC, FC
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H
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110.0kDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1,000-1:2,000
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1:10-1:50
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1:50-1:200
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1:50-1:200
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1:50-1:200
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1:50-1:100
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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PMS2 Rabbit
Monoclonal Antibody
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Category
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Rabbit
Monoclonal Antibody (RabMAb); Primary antibody
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Isotype
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IgG
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Purification
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XYfinity
purification
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About the
Immunogen
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Immunogen
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Recombinant
protein
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Gene ID
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441194(Human)
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SwissProt
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P54278(Human)
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Synonyms
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PMS2P13
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Category
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Epigenetics
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Background
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The finding
that mutations in DNA mismatch repair genes are associated with hereditary
nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest
in the understanding of the mechanism of DNA mismatch repair. Initially,
inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA
mismatch repair genes MutS and MutL were demonstrated at high frequency in
HNPCC and were shown to be associated with microsatellite instability. The
demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and
small cell lung cancers also display microsatellite instability has been
interpreted to suggest that DNA mismatch repair is not restricted to HNPCC
tumors but is a common feature in tumor initiation or progression. Two
additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2,
have been identified and shown to be mutated in the germline of HNPCC
patients.
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包装清单:
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产品编号
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产品名称
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包装
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XY1339
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PMS2 Rabbit
Monoclonal Antibody
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50μl
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XY050
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Western一抗稀释液
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50ml
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-
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说明书
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1份
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保存条件:
PMS2 Rabbit
Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项:
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10