SIRT1 Rabbit Polyclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
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XY0282
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SIRT1 Rabbit
Polyclonal Antibody
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50μl
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416.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, FC, IHC
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H, M
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110KDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk, Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all
species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1000-1:2000
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-
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-
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1:200
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-
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1:100-1:200
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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SIRT1 Rabbit
Polyclonal Antibody
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Category
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Polyclonal
antibody(pAb); Primary antibody
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Isotype
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IgG
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Purification
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Peptide XYfinity
purified
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About the
Immunogen
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Immunogen
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This antibody
is produced by immunizing rabbits with a synthetic peptide (KLH-coupled)
corresponding to C-terminal of SIRT1.
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Gene ID
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23411
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SwissProt
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Q96EB6
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Synonyms
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EC 3.5.1.-;
hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2-like protein
1; SIR2L1; sirtuin 1
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Category
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Chromatin
Regulation / Nuclear Function
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Background
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SirT1, the
mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation
of many cellular processes, including apoptosis, cellular senescence,
endocrine signaling, glucose homeostasis, aging, and longevity. Targets of
SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription
factors, PPARγ, and the PPARγ coactivator-1α (PGC-1α) protein. Deacetylation of p53
and FoxO transcription factors represses apoptosis and increases cell
survival. SirT1 deacetylase activity is inhibited by nicotinamide and
activated by resveratrol.
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包装清单：
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产品编号
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产品名称
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包装
|
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XY0282
|
SIRT1 Rabbit
Polyclonal Antibody
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50μl
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AZ050
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Western一抗稀释液
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50ml
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|
—
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说明书
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1份
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保存条件：
SIRT1 Rabbit
Polyclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。
注意事项：
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10