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Background
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ROCK1 is a
protein serine/threonine kinase also known as rho-associated,
coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue
distribution, but subcellularly it is thought to colocalize with the
centrosomes. This is consistent with its function as a key modulator of cell
motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has
a diverse range of functions in the body. It is a key regulator of
actin-myosin contraction, stability, and cell polarity. These contribute to many
progresses such as regulation of morphology, gene transcription,
proliferation, differentiation, apoptosis and oncogenic transformation. Other
functions involve smooth muscle contraction, actin cytoskeleton organization,
stress fiber and focal adhesion formation, neurite retraction, cell adhesion
and motility. These functions are activated by phosphorylation of DAPK3,
GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A.
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