Cyclin D1 Rabbit Polyclonal Antibody
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产品编号
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产品名称
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产品包装
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产品价格
|
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XY0126
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Cyclin D1
Rabbit Polyclonal Antibody
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50μl
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416.00元
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来源
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用途
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交叉反应性
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分子量
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Rabbit
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WB, IHC
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H, M, R
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36KDa
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WB, Western blot;
IP, Immunoprecipitation; IF, Immunofluorescence; IHC, Immunohistochemistry;
ICC,
Immunocytochemistry; FC, Flow Cytometry; ELISA, Enzyme-linked Immunosorbent
Assay; ChIP, Chromatin
Immunoprecipitation Assay.
H, Human; M,
Mouse; R, Rat; C, Chicken; Cw, Cow; Dg, Dog; Gp, Guinea pig; Hm, Hamster; Hr,
Horse; Mk,
Monkey; Pg, Pig; Rb, Rabbit; S, Sheep; Z, ZebrXYish; All, all species expected.
配套提供了Western一抗稀释液，可以用于Western检测或其它适当用途时的一抗稀释。
建议抗体使用时的稀释比例如下(实际使用时需根据抗原水平的高低作适当调整)：
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WB
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IP
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IF
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IHC
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ICC
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FC
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ELISA
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ChIP
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1:1000
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-
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-
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1:100
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-
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-
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-
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-
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抗体详细信息如下:
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About this
Antibody
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Name
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Cyclin D1
Rabbit Polyclonal Antibody
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Category
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Polyclonal
antibody(pAb); Primary antibody
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Isotype
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IgG
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Purification
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Peptide XYfinity
purified
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About the
Immunogen
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Immunogen
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This antibody
is produced by immunizing rabbits with a synthetic peptide (KLH-coupled)
corresponding to N-terminal residues of mouse Cyclin D1.
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Gene ID
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595
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SwissProt
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P24385
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Synonyms
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CCND1;BCL1;
D11S287E; PRAD1; U21B31
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Category
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Cell Cycle /
Checkpoint Control
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Background
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Cyclins
function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins
exhibit distinct expression and degradation patterns which contribute to the
temporal coordination of each mitotic event. This cyclin forms a complex with
and functions as a regulatory subunit of CDK4 or CDK6, whose activity is
required for cell cycle G1/S transition. Cyclin D1 has been shown to interact
with tumor suppressor protein Rb and the expression of this gene is regulated
positively by Rb. Mutations, amplification and overexpression of this gene,
which alters cell cycle progression, are observed frequently in a variety of
tumors and may contribute to tumorigenesis. Immunohistochemical staining of
cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has
been found to be overexpressed in breast carcinoma. Its potential use as a
biomarker was suggested .
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包装清单：
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产品编号
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产品名称
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包装
|
|
XY0126
|
Cyclin D1
Rabbit Polyclonal Antibody
|
50μl
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AZ050
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Western一抗稀释液
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50ml
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|
—
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说明书
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1份
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保存条件：
Cyclin D1 Rabbit
Polyclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物
注意事项：
如果本抗体用于Western blot (WB)、**荧光(IF)、**细胞化学(ICC)等实验，请注意回收使用过的稀释抗体?；厥盏目固逋ǔＶ辽倏梢灾馗词褂?span>5-10