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产品名称: Recombinant Human MIC-B
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Human MIC-B由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Human MIC-B所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Human MIC-B
的详细介绍
Recombinant Human MIC-B
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产品编号
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产品名称
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产品包装
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产品价格
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XY7149-1mg
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Recombinant
Human MIC-B
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1mg
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12354.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Human
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4277
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Q29980
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E. coli
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287aa
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32.8kDa
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－
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About this
Antibody
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Name
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Recombinant
Human MIC-B (Recombinant Human MHC Class I PolypeptideRelated Sequence B;
rHuMIC-B)；重组人MIC类多肽相关序列B
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Synonyms
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MHC class I
chain-related protein B; MHC class I mic-B antigen; MHC class I
polypeptide-related sequence B; MIC-B; PERB11.2MHC class I-like molecule
PERB11.2-IMX; stress inducible class I homolog
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Purity
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>95% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Fully
biologically active when compared to standard. The specific activity is
determined by binding MICB antibody in ELISA.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in 20mM Tris, 150mM
NaCl, pH8.0.
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Endotoxin
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Less than 1EU/μg of rHuMIC-B as determined by LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions
should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Others
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Background
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MIC-B (MHC
class I chain-related gene B) is a single-pass type I member protein. It is
widely expressed in many, but not all, epithelial tumors of lung, breast,
kidney, ovary, prostate and colon. In addition to this, it is produced by
hepatocellular carcinomas, which is only in tumor cells but not in
surrounding non-cancerous tissue and can be induced by bacterial and viral
infections. MIC-B shares 85% amino acid identity with MIC-A and they are
distantly related to the MHC class I proteins. Because they possess three
extracellular Ig-like domains, but unlike classical MHC class I molecules,
they do not form a heterodimer with beta2 microglobulin, but bind as a
monomer to a KLRK1/NKG2D that is an activating receptor expressed on NK
cells, NKT cells, γδ T cells, and CD8+ αβ T cells. Recognition of MIC-B by
NKG2D results in the activation of cytolytic activity and/or cytokine
production by these effector cells. MIC-B recognition plays an important role
in tumor surveillance, viral infections, and autoimmune diseases.
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Amino Acid
Sequence
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AEPHSLRYNL MVLSQDESVQ SGFLAEGHLD
GQPFLRYDRQ KRRAKPQGQW AEDVLGAKTW DTETEDLTEN GQDLRRTLTH IKDQKGGLHS LQEIRVCEIH
EDSSTRGSRH FYYDGELFLS QNLETQESTV PQSSRAQTLA MNVTNFWKED AMKTKTHYRA MQADCLQKLQ
RYLKSGVAIR RTVPPMVNVT CSEVSEGNIT VTCRASSFYP RNITLTWRQD GVSLSHNTQQ WGDVLPDGNG
TYQTWVATRI RQGEEQRFTC YMEHSGNHGT HPVPSGKVLV LQSQRTD
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包装清单:
|
产品编号
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产品名称
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包装
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XY7149-10μg
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Recombinant
Human MIC-B
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10μg
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XY7149-50μg
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Recombinant
Human MIC-B
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50μg
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XY7149-100μg
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Recombinant
Human MIC-B
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100μg
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XY7149-1mg
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Recombinant
Human MIC-B
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。