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产品名称: Recombinant Ovine IFN-τ
产品型号:
产品展商: XYbscience
产品文档: 无相关文档
简单介绍
Recombinant Ovine IFN-τ由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。Recombinant Ovine IFN-τ所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
Recombinant Ovine IFN-τ
的详细介绍
Recombinant Ovine IFN-τ
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产品编号
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产品名称
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产品包装
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产品价格
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XY6447-1mg
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Recombinant
Ovine IFN-τ
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1mg
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27053.00元
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Species
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Gene ID
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Accession
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Source
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Length
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MW
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Tag
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Ovine
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10014475
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P56828
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Yeast
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172aa
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19.9kDa
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－
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About this
Antibody
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Name
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Recombinant
Ovine IFN-τ (Recombinant Ovine Interferon-τ; rOvIFN-τ)；重组羊干扰素τ
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Synonyms
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OTP; IFNT1;
IFNT3; IFNT4; IFNT7; IFNT8; IFNT9; TP-07; TP-08; TP-010; IFN-tau-3;
IFN-tau-7; IFN-tau-8; IFN-tau-9; IFN-tau-1; Antiluteolysin; Trophoblast
antiluteolytic protein; Trophoblast protein 1; TP-1
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Purity
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>97% by
SDS-PAGE and HPLC analyses.
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Biological
Activity
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Fully
biologically active when compared to IFN-alpha. The specific activity
determined by a viral resistance assay is no less than 1.0×107IU/mg.
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Physical
Appearance
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Sterile
Filtered White lyophilized (freeze-dried) powder.
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Formulation
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Lyophilized
from a 0.2μm filtered concentrated solution in PBS, pH7.4.
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Endotoxin
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Less than
0.1EU/μg of rOvIFN-τ as determined by
LAL method.
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Reconstitution
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We recommend
that this vial be briefly centrifuged prior to opening to bring the contents
to the bottom. Reconstitute in sterile distilled water or aqueous buffer
containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions
should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in
appropriate buffered solutions.
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Category
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Cytokine
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Background
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IFN-τ is a new class of type I IFN that is secreted by the trophoblast
and is the signal for maternal recognition of pregnancy in sheep. IFN-τ has potent immunosuppressive and antiviral activities similar to
other type I IFN but is less cytotoxic than IFN-α/β. The current investigation concerns the effect of recombinant
ovine IFN-tau (rOvIFN-τ) on the modulation of MHC
class I and II expression on cloned mouse cerebrovascular endothelial (CVE)
cells. IFN-tau induced tyrosine phosphorylation of Stat1 and up regulated the
expression of MHC class I on CVE. One proposed action by which type I IFN
reduce the relapse rate in MS is via interference with IFN-γ-induced MHC class II expression. IFN-τ was shown to down regulate IFN-γ-induced MHC class II
expression on CVE and, hence, may be of potential therapeutic value in down
regulating inflammation in the central nervous system (CNS). IFN-τ did not upregulate the expression of MHC class II on CVE. IFN-τ also inhibited the replication of Theiler's virus in CVE.
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Amino Acid
Sequence
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CYLSRKLMLD ARENLKLLDR MNRLSPHSCL
QDRKDFGLPQ EMVEGDQLQK DQAFPVLYEM LQQSFNLFYT EHSSAAWDTT LLEQLCTGLQ QQLDHLDTCR
GQVMGEEDSE LGNMDPIVTV KKYFQGIYDY LQEKGYSDCA WEIVRVEMMR ALTVSTTLQK RLTKMGGDLN
SP
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包装清单:
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产品编号
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产品名称
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包装
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XY6447-2μg
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Recombinant
Ovine IFN-τ
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2μg
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XY6447-10μg
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Recombinant
Ovine IFN-τ
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10μg
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XY6447-100μg
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Recombinant
Ovine IFN-τ
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100μg
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XY6447-1mg
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Recombinant
Ovine IFN-τ
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1mg
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-
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说明书
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1份
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保存条件:
-20℃或更低温度保存，至少一年有效。由于蛋白的每次冻融均会引起部分失活，所以**配制成相应浓度的储存液后(请根据产品简介中Reconstitution一栏的信息配制储存液)，须分装后-20℃或更低温度冻存，以避免反复冻融。
注意事项:
由于有些塑料管壁对某些蛋白有较强的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很难与管壁分离。而载体蛋白(Carrier protein，如0.1% BSA等)的主要作用是预先封闭塑料管壁上的蛋白结合位点，使细胞因子或重组蛋白不会粘附于管壁。所以一定要使用产品简介中Reconstitution一栏的信息配制储存液。
本产品**于专业人员的科学研究用，不得用于临床诊断或**，不得用于食品或药品，不得存放于普通住宅内。
为了您的**和健康，请穿实验服并戴一次性手套操作。