Notch信号通路Delta样配体3抗体
规格：1mg/1ml
英文名： DLL3
别名： Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; Delta3; Drosophila Delta homolog 3; SCDO1; Spondylocostal dysos
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DLL3
交叉反应：Human, Mouse, Dog, Cow, Horse, Rabbit,
细胞定位：细胞膜
Notch信号通路Delta样配体3抗体产品介绍：background: Delta-like 3 (DLL3) is a transmembrane Delta-like protein that inhibits primary neurogenesis. It may be required to divert neurons along a specific differentiation pathway and plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 is one of five DSL proteins that bind to the Notch receptor and activates Notch signaling. Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Subunit: Can bind and activate Notch-1 or another Notch receptor (Probable). Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis. Post-translational modifications: Ubiquitinated by MIB (MIB1 or MIB2), leadingNotch信号通路Delta样配体3抗体 to its endocytosis and subsequent degradation. DISEASE: Note=A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities. Similarity: Contains 1 DSL domain. Contains 6 EGF-like domains. Database links: Entrez Gene: 505993 Cow Entrez Gene: 10683Notch信号通路Delta样配体3抗体 Human Entrez Gene: 100520433 Pig Omim: 602768 Human SwissProt: Q9NYJ7 Human Unigene: 127792 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Notch信号通路Delta样配体3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 信号转导 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid