细胞膜钙ATP酶4B抗体
规格：1mg/1ml
英文名： PMCA4B
别名： PMCA4b; PMCA4x; AT2B4_HUMAN; ATP2B2; ATPase Ca++ transporting plasma membrane 4; Cation transporting ATPase; DKFZp686G08106; DKFZp686M088; Matrix remodelling associated 1; Matrix remodelling associate
分子量： 130kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PMCA4B
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
产品介绍：background: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation 细胞膜钙ATP酶4B抗体of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.细胞膜钙ATP酶4B抗体 [provided by RefSeq, Jul 2008]. Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Subcellular Location: Cell membrane. Tissue Specificity: Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been细胞膜钙ATP酶4B抗体 found in heart, stomach and brain cortex. Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Database links: UniProtKB/Swiss-Prot: P23634.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞膜钙ATP酶4B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid