瞬时受体电位离子通道蛋白1抗体
规格：1mg/1ml
英文名： TRPM1
别名： Long transient receptor potential channel 1; LTRPC1; Melastatin 1; Melastatin-1; MLSN1; Transient receptor potential cation channel subfamily M member 1; Transient receptor potential cation channel, s
分子量： 182kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRPM1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
瞬时受体电位离子通道蛋白1抗体产品介绍：background: Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Involvement in disease: Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Function: Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Subcellular Location: Cell membrane Tissue Specificity: Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in瞬时受体电位离子通道蛋白1抗体benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing. DISEASE: Defects in TRPM1 are the cause of congenital stationary night blindness type 1C (CSNB1C) [MIM:613216]. A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. Database links: Entrez Gene: 4308 Human Entrez Gene: 17364瞬时受体电位离子通道蛋白1抗体 Mouse Entrez Gene: 361586 Rat Omim: 603576 Human SwissProt: O75560 Human SwissProt: Q7Z4N2 Human SwissProt: Q2TV84 Mouse SwissProt: Q2WEA4 Rat SwissProt: Q2WEA5 Rat Unigene: 155942 Human Unigene: 38875 Mouse Unigene: 211311 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
瞬时受体电位离子通道蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid