端粒酶相关蛋白1抗体
规格：1mg/1ml
英文名： TEP1
别名： Telomerase Associated pratein-1; TEP1; TLP1; TP1 TP-1; Telomerase protein component 1; Telomerase protein 1; p240; p80 telomerase homolog; TEP1_HUMAN; Telomerase associated protein 1; Telomerase prote
分子量： 290kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TP-1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
端粒酶相关蛋白1抗体产品介绍：background: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist. Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also端粒酶相关蛋白1抗体 component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Subcellular Location: Nucleus (Probable). Telomere. Tissue Specificity: Ubiquitous. Similarity:端粒酶相关蛋白1抗体 Contains 1 NACHT domain. Contains 4 TEP1 N-terminal repeats. Contains 1 TROVE domain. Contains 21 WD repeats. Gene ID: 7011 Database links: Entrez Gene: 7011 Human Entrez Gene: 21745 Mouse Entrez Gene: 64523 Rat SwissProt: Q99973 Human SwissProt: P97499 Mouse SwissProt: O08653 Rat Unigene: 508835 Human Unigene: 318736 Mouse Unigene: 5890 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
端粒酶相关蛋白1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid