丝裂原活化蛋白激酶底物1抗体
规格：1mg/1ml
英文名： SAKS1/2B28
别名： LOC51035 2B28; 4930455J02Rik; D19Ertd721e; MGC124706; MGC6696; mY33K; UBXN1_HUMAN; Protein 2B28; RGD1309471; SAKS1; SAPK substrate protein 1; T25529; UBA/UBX 33.3 kDa protein; UBX domain containing pr
分子量： 33kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SAKS1/2B
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
丝裂原活化蛋白激酶底物1抗体产品介绍：background: 2B28 is a component of a complex composed of NGLY1, SAKS1, AMFR, VCP and RAD23B, where it acts as an adapter that directs VCP to polyubiquitinated proteins. 2B28 also interacts with Homer 2, which further suggests role for 2B28 in the regulation of protein degradation by ubiquitin-proteasome systems. Function: Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems. 2 named isoforms exist. Subunit: Component of a complex required to 丝裂原活化蛋白激酶底物1抗体couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not 丝裂原活化蛋白激酶底物1抗体autoubiquitinated but is strongly enhanced in the presence of autoubiquitinated BRCA1. Subcellular Location: Cytoplasm Similarity: Belongs to the mitochondrial carrier (TC 2.A.29) family. Gene ID: 51035 Database links: Entrez Gene: 51035 Human Entrez Gene: 225896 Mouse Entrez Gene: 293719 Rat SwissProt: Q04323 Human SwissProt: Q922Y1 Mouse SwissProt: Q499N6 Rat Unigene: 351296 Human Unigene: 27839 Mouse Unigene: 198539 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝裂原活化蛋白激酶底物1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid