磷脂酸磷酸酶LPIN3抗体
规格：1mg/1ml
英文名： Lipin 3
别名： dJ450M14.2; dJ450M14.3; dJ620E11.2; Lipin 3 like; Lipin-3; Lipin-3-like; Lipin3; LIPN3L; LPIN 3; LPIN3; LPIN3_HUMAN; Phosphatidate phosphatase LPIN3; RP4 620E11.3; SMP2.
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Lipin 3
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
磷脂酸磷酸酶LPIN3抗体产品介绍：background: Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three磷脂酸磷酸酶LPIN3抗体 human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively. [provided by RefSeq, Jul 2008] Function: Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Subcellular Location: Nucleus. Tissue Specificity: Significant 磷脂酸磷酸酶LPIN3抗体expression in intestine and other regions of the gastrointestinal tract. Similarity: Belongs to the lipin family. Gene ID: 64900 Database links: Entrez Gene: 64900 Human Entrez Gene: 64899 Mouse SwissProt: Q9BQK8 Human SwissProt: Q99PI4 Mouse Unigene: 25897 Human Unigene: 528618 Human Unigene: 292111 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷脂酸磷酸酶LPIN3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid