T**细胞活化蛋白样蛋白MRFAP1L1抗体
规格：1mg/1ml
英文名： MRFAP1L1
别名： MORF4 family-associated protein 1-like 1; MR1L1_HUMAN; MRFAP1L1; PP784. RBP1_HUMAN
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MRFAP1L1
交叉反应：Human,
细胞定位：细胞核 细胞浆
T**细胞活化蛋白样蛋白MRFAP1L1抗体产品介绍：background: The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. MORF4 family-associated protein 1 (MRFAP1), also known as GAM14 or PGR1, is a 127 amino acid member of the MORF4 family-associated protein family. Localized to nucleus and cytoplasm, MRFAP1 colocalizes with MORF4L1 to the cell nuclei. Its association with MORF4L1 and Rb1 suggests that MRFAP1 may play a role in transcription regulation. The gene encoding human MRFAP1 maps to chromosome 4p16.1. Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX)and is the major ATPT**细胞活化蛋白样蛋白MRFAP1L1抗体-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. Subunit: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this T**细胞活化蛋白样蛋白MRFAP1L1抗体does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Subcellular Location: Membrane Tissue Specificity: Expressed ubiquitously but at low levels.Shows a strong expression in the erythrocytes. Similarity: Belongs to the MORF4 family-associated protein family. Gene ID: 114932 Database links: Entrez Gene: 114932 Human SwissProt: Q96HT8 Human Unigene: 593159 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
T**细胞活化蛋白样蛋白MRFAP1L1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid