三磷酸腺苷结合盒转运体3抗体
规格：1mg/1ml
英文名： ABCA3/P180 Lamellar Body Protein
别名： ABC 3; ABC C; ABC C transporter; ABC transporter 3; ABC-C transporter; ABC3; ABCA 3; Abca3; ABCA3 protein; ABCA3_HUMAN; ABCC; ATP binding cassette 3; ATP binding cassette sub family A (ABC1) member 3;
分子量： 191kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ABCA3/P1
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：细胞膜
三磷酸腺苷结合盒转运体3抗体产品介绍：background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008] Function: Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. Subcellular Location: Membrane. Tissue Specificity: Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in 三磷酸腺苷结合盒转运体3抗体placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. DISEASE: Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive 三磷酸腺苷结合盒转运体3抗体lipoproteins accumulation in the alveoli results in severe respiratory distress. Similarity: Belongs to the ABC transporter superfamily. ABCA family. Contains 2 ABC transporter domains. Gene ID: 21 Database links: Entrez Gene: 21 Human Entrez Gene: 27410 Mouse Entrez Gene: 302973 Rat Omim: 601615 Human SwissProt: Q99758 Human SwissProt: Q8R420 Mouse Unigene: 26630 Human Unigene: 239470 Mouse Unigene: 233424 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
三磷酸腺苷结合盒转运体3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转运蛋白 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid