黑素细胞特异性转运蛋白抗体
规格：1mg/1ml
英文名： P protein
别名： BEY; BEY1; BEY2; BOCA; D15S12; EYCL; EYCL2; EYCL3; eye color 2 (central brown); eye color 3 (brown); hair color 3 (brown); HCL3; Melanocyte-specific transporter protein; OCA2; oculocutaneous albinism
分子量： 93kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human P protei
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig,
细胞定位：细胞膜
黑素细胞特异性转运蛋白抗体产品介绍：background: This gene encodes the human homologue of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine - a precursor of melanin. Mutations in this gene result in type 2 oculocutaneous albinism. [provided by RefSeq, Jul 2008] Function: Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Subcellular Location: Melanosome membrane. DISEASE: Defects in OCA2 are the cause of albinism 黑素细胞特异性转运蛋白抗体oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light黑素细胞特异性转运蛋白抗体 brown hair and skin color and gray to tan irides. Similarity: Belongs to the CitM (TC 2.A.11) transporter family. Gene ID: 4948 Database links: Entrez Gene: 488683 Dog Entrez Gene: 100724327 Guinea pig Entrez Gene: 100034107 Horse Entrez Gene: 4948 Human Entrez Gene: 18431 Mouse Entrez Gene: 397171 Pig Entrez Gene: 24606 Rat Entrez Gene: 567419 Zebrafish Omim: 611409 Human SwissProt: Q04671 Human SwissProt: Q62052 Mouse SwissProt: Q8MIQ9 Pig Unigene: 654411 Human Unigene: 137052 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
黑素细胞特异性转运蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid