组蛋白H3.1抗体
规格：1mg/1ml
英文名： Histone H3.1
别名： H3 histone family, member A; H3 histone family, member B; H3 histone family, member C; H3 histone family, member D; H3 histone family, member E; H3 histone family, member F; H3 histone family, member
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Histone
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Chimpanzee,
细胞定位：细胞核
组蛋白H3.1抗体产品介绍：background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008] Function: Histone H3.1 is a core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of组蛋白H3.1抗体 post-translational modifications of histones, also called histone code, and nucleosome remodelling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3 H4 heterotetramer and two H2A H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Subcellular Location: Nuclear Similarity: Belongs to the histone H3 family. Gene ID: 8350 Database links: Entrez Gene: 8350 Human Entrez Gene: 8351 Human Entrez Gene: 8352 Human Entrez Gene: 8353 Human Entrez Gene: 8354 Human Entrez Gene: 8355 Human Entrez Gene: 8356 Human Entrez Gene: 8357 Human Entrez Gene: 8358 Human Entrez Gene: 8968 Human Entrez Gene: 319148 Mouse Entrez Gene: 319151 Mouse Entrez Gene: 319152 Mouse Entrez Gene: 319153 Mouse Entrez Gene: 360198 Mouse Entrez Gene: 97908 Mouse Omim: 602810 Human Omim: 602811 Human Omim: 602812 Human Omim: 602813 Human Omim: 602814 Human Omim: 602815 Human Omim: 602816 Human Omim: 组蛋白H3.1抗体602817 Human Omim: 602818 Human Omim: 602819 Human SwissProt: P68431 Human SwissProt: P68433 Mouse Unigene: 132854 Human Unigene: 247813 Human Unigene: 247814 Human Unigene: 248176 Human Unigene: 443021 Human Unigene: 484990 Human Unigene: 532144 Human Unigene: 533292 Human Unigene: 546315 Human Unigene: 586261 Human Unigene: 591778 Human Unigene: 626666 Human Unigene: 221301 Mouse Unigene: 261657 Mouse Unigene: 377874 Mouse Unigene: 390558 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白H3.1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid