绒毛膜癌不表达蛋白1抗体
规格：1mg/1ml
英文名： HOPX
别名： CAMEO; heart odd homeobox 1 protein; HOD; Homeodomain-only protein; HOP; HOP homeobox; HOP_HUMAN; HOPX; LAGY; Lung cancer-associated Y protein; NECC1; Not expressed in choriocarcinoma clone 1; Not exp
分子量： 8kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HOPX
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞核
绒毛膜癌不表达蛋白1抗体产品介绍：background: The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009] Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of绒毛膜癌不表达蛋白1抗体 SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer绒毛膜癌不表达蛋白1抗体 such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. Similarity: Contains 1 homeobox DNA-binding domain. Gene ID: 84525 Database links: Entrez Gene: 281270 Cow Entrez Gene: 84525 Human Entrez Gene: 74318 Mouse Entrez Gene: 396692 Pig Entrez Gene: 171160 Rat Omim: 607275 Human SwissProt: Q8MJD5 Cow SwissProt: Q9BPY8 Human SwissProt: Q8R1H0 Mouse SwissProt: Q8MJD6 Pig SwissProt: Q78ZR5 Rat Unigene: 619396 Human Unigene: 181852 Mouse Unigene: 478741 Mouse Unigene: 2989 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
绒毛膜癌不表达蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid