甘露聚糖结合凝集素丝氨酸肽酶1抗体
规格：1mg/1ml
英文名： MASP1/MASP3
别名： MASP1/3; Complement factor MASP-3; Complement factor MASP3; Complement-activating component of Ra-reactive factor; CRARF; EC 3.4.21; Mannan binding lectin serine protease 1; Mannose binding lectin ass
分子量： 54,77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MASP
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞浆 细胞膜
甘露聚糖结合凝集素丝氨酸肽酶1抗体产品介绍：background: MASP is a component of the bactericidal ra-reactive factor rarf which specifically binds to RA and R2 polysaccharides expressed by certain enterobacteria. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4. The alternative-splicing product from MASP1 gene is called MASP3. MASP1 is associated with smaller MBL oligomers whereas MASP3 is found on larger oligomers. The substrate of MASP3 is unknown. Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the 甘露聚糖结合凝集素丝氨酸肽酶1抗体S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Normal mammary epithelial cells. Similarity: Belongs to the serpin family. Ov-serpin subfamily. Gene ID: 5268 Database links: Entrez Gene: 5268 Human Entrez Gene: 20724 Mouse Entrez Gene: 甘露聚糖结合凝集素丝氨酸肽酶1抗体116589 Rat Omim: 154790 Human SwissProt: P36952 Human SwissProt: P70124 Mouse SwissProt: P70564 Rat Unigene: 55279 Human Unigene: 268618 Mouse Unigene: 25752 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 甘露糖结合凝集素(MBL)是补体系统的原有成分，是由肝脏合成的C型凝集素并游离在血清中，也是钙依赖性糖结合蛋白。 MBL可识别和结合病原微生物表面的甘露糖、岩藻糖和N-乙酰葡糖胺等糖结构并首先与病原微生物的糖类配体结合，随后构象发生变化，激活与之相关联的MBL相关的丝氨酸蛋白激酶(MASP)，两种MASP(MASP1、MASP2)具有与活化的C1s类似的生物学活性，其中MASP2可水解C4和C2分子，MASP1则可直接切割C3，而形成C3转化酶，以至补体顺序激活，这是补体激活的MBL途径，这种补体顺序的被激活在机体的固有性**防御中发挥重要作用。
甘露聚糖结合凝集素丝氨酸肽酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid