甲状腺受体相互作用蛋白8抗体
规格：1mg/1ml
英文名： JMJD1C
别名： JHD2C_HUMAN; Jmjd1c; Jumonji domain containing 1C; Jumonji domain-containing protein 1C; Probable JmjC domain-containing histone demethylation protein 2C; Thryoid receptor interacting protein; Thyroid
分子量： 284kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human JMJD1C
交叉反应：Human, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
甲状腺受体相互作用蛋白8抗体产品介绍：background: JMJD1C is a nuclear protein that belongs to the JHDM2 family of histone demethylases. Expressed in a wide variety of tissues, JMJD1C binds iron as a cofactor and contains one JMJC domain, a TRI8H1 domain with a C2HC4-type zinc finger-like motif and a TRI8H2 domain with a TR∫ (thyroid hormone receptor ∫)-binding region. JMJD1C demethylates lysine-9 of Histone H3, thereby playing a central role in the histone code and participating in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1C plays an important role in the regulation of cell growth during development and in chromatin regulation. Due to alternative splicing events, two isoforms exist for JMJD1C. One of these isoforms functions as a coactivator for the AR (androgen receptor). Function: Probable histone甲状腺受体相互作用蛋白8抗体 demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably 甲状腺受体相互作用蛋白8抗体by ATM or ATR. Similarity: Belongs to the JHDM2 histone demethylase family. Contains 1 JmjC domain. Gene ID: 221037 Database links: Entrez Gene: 221037 Human Entrez Gene: 108829 Mouse Entrez Gene: 171120 Rat NCBI: NP_004232.2 Human Omim: 604503 Human SwissProt: Q15652 Human SwissProt: Q69ZK6 Mouse SwissProt: Q6NV48 Mouse Unigene: 413416 Human Unigene: 499821 Human Unigene: 23846 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甲状腺受体相互作用蛋白8抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid