TPIT蛋白抗体
规格：1mg/1ml
英文名： TPIT
别名： DJ747L4.1; T Box 19; T box factor, pituitary; T box protein 19; T box transcription factor TBX19; T box transcription factor TBX19; TBS 19; TBS19; TBX19; TPIT.
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TPIT
交叉反应：Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Chimpanzee,
细胞定位：细胞核
TPIT蛋白抗体产品介绍：background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008] Function: Tpit (TBX19, T box 19) is a highly cell-restricted transcription factor belonging to the T-Box family. T box 19 is required for pro-opeiomelanocortin (POMC) gene expression and differentiation TPIT蛋白抗体of corticotroph and melanotroph cells. Tpit gene mutations have been shown to be directly correlated to pituitary adrenocorticotropin (ACTH) deficiencies. Tpit functions as a transcriptional activator by recruiting the p160 family of coactivators. Subcellular Location: Nuclear Similarity: Contains 1 T-box DNA-binding domain. Gene ID: 9095 Database links: Entrez Gene: 395793 Chicken Entrez Gene: 514352 Cow Entrez Gene:TPIT蛋白抗体 449029 Dog Entrez Gene: 9095 Human Entrez Gene: 83993 Mouse Entrez Gene: 304935 Rat Omim: 604614 Human SwissProt: O60806 Human SwissProt: Q99ME7 Mouse Unigene: 190649 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TPIT蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid