TRMT12蛋白抗体
规格：1mg/1ml
英文名： TRMT12
别名： Alpha amino alpha carboxypropyl transferase TYW2; FLJ20772; Homolog of yeast tRNA methyltransferase; Radical S-adenosyl methionine and flavodoxin domain-containing protein 2; TRM 12; TRM12; TRMT 12; T
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRMT12
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
TRMT12蛋白抗体产品介绍：background: Transfer RNA (tRNA) modifications help regulate the efficiency of mRNA translation by maintaining the correct reading frames. TRM12 (tRNA methyltransferase 12 homolog (S. cerevisiae)), also known as TYW2 (tRNA-yW-synthesizing protein 2) or TRMT12, is a 448 amino acid protein that belongs to the RNA methyltransferase trmD family and TYW2 subfamily. TRM12 is the human homolog of a yeast gene that is essential for the synthesis of yW (wybutosine), a guanosine that stabilizes codon-anticodon associations near the anticodon of phenylalanine tRNA during ribosomal decoding. The gene encoding TRRM12 maps to human chromosome 8, which consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder,TRMT12蛋白抗体 Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. Function: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3TRMT12蛋白抗体'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Similarity: Belongs to the RNA methyltransferase trmD family. TYW2 subfamily. Gene ID: 55039 Database links: Entrez Gene: 55039 Human Entrez Gene: 68260 Mouse Omim: 611244 Human SwissProt: Q53H54 Human SwissProt: Q8BG71 Mouse Unigene: 9925 Human Unigene: 278805 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRMT12蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit