TRIO蛋白抗体
规格：1mg/1ml
英文名： TRIO
别名： ARHGEF23; PTPRF-interacting protein; tgat; trio; TRIO_HUMAN; Triple functional domain protein.
分子量： 347kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRIO
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞浆
TRIO蛋白抗体产品介绍：background: Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane-associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPa, PTPb, PTPg, PTPd, PTPe, PTPz, PTPk and PTPm. Transmembrane PTPs play diverse roles during development and in ***** tissues. Immunodepletion studies have suggested LAR to be a regulator of insulin receptor phosphorylation. Trio is a LAR-interacting protein that contains two functional guanine nuclear exchange factor (GEF) domains and a serine/threonine protein kinase (PSK) domain. One of the the Trio-GEF domains exhibits Rac-specific GEF activity while the other exibits Rho-specific GEF activity. The carboxy terminal PSK domain is most similar to the PSK domains of the CaMK family. Function:TRIO蛋白抗体 Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. Subunit: Interacts to form a complex with leukocyte antigen related protein. Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung. Post-translational modifications: Phosphorylated on serine residue(s). Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinaseTRIO蛋白抗体 family. Contains 1 CRAL-TRIO domain. Contains 2 DH (DBL-homology) domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 PH domains. Contains 1 protein kinase domain. Contains 2 SH3 domains. Contains 4 spectrin repeats. Gene ID: 7204 Database links: Entrez Gene: 7204 Human Omim: 601893 Human SwissProt: O75962 Human Unigene: 130031 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRIO蛋白抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid