LARP7蛋白抗体
规格：1mg/1ml
英文名： LARP7
别名： DKFZp564K112; HDCMA18P; La related protein 7; La ribonucleoprotein domain family member 7; La ribonucleoprotein domain family member 7; La-related protein 7; LARP 7; larp7; LARP7_HUMAN; MGC104360; P T
分子量： 67kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LARP7
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：细胞核
LARP7蛋白抗体产品介绍：background: This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012] Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, LARP7蛋白抗体preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Subcellular Location: Nucleus > nucleoplasm. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 HTH La-typeLARP7蛋白抗体 RNA-binding domain. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 51574 Database links: Entrez Gene: 51574 Human Entrez Gene: 28036 Mouse Entrez Gene: 686883 Rat Omim: 612026 Human SwissProt: Q4G0J3 Human SwissProt: Q05CL8 Mouse SwissProt: Q5XI01 Rat Unigene: 713663 Human Unigene: 291032 Mouse Unigene: 168323 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LARP7蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid