碳酸酐酶2抗体
规格：1mg/1ml
英文名： CA II
别名： Carbonic anhydrase Ⅱ; CA 2; CA II; CA2; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2 ; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CA II
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
碳酸酐酶2抗体产品介绍：background: Carbonic anhydrase II (CAII) is a single polypeptide chain of molecular weight 29kDa. It is present in the cytosol of most tissues, but highest concentrations are found, like Carbonic Anhydrase I, in erythrocytes. The concentration in erythrocytes is about 20μM. It catalyses the hydration of CO2 and the hydrolysis of esters. Zn2+ ion cofactor is required for enzyme activity. Certain point mutations occur without apparent clinical effect, however, complete absence leads to mild mental retardation and cerebral calcification, osteoporosis and renal tubular acidosis. Also known as: Carbonic anhydrase Ⅱ; CA 2; CA II; CA2; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2 ; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase II; Carbonic dehydratase. Function: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation 碳酸酐酶2抗体of fluid secretion into the anterior chamber of the eye. Subunit: Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Subcellular Location: Cytoplasm. DISEASE: Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The碳酸酐酶2抗体 disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation. Similarity: Belongs to the alpha-carbonic anhydrase family. Gene ID: 760 Database links: Entrez Gene: 760 Human Entrez Gene: 12349 Mouse Omim: 611492 Human SwissProt: P00918 Human SwissProt: P00920 Mouse Unigene: 155097 Human Unigene: 1186 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CA2(Carbonic anhydrase1)也是红细胞的主要蛋白质成分之一,是一种重要的锌酶，对血液及组织起到维持酸碳酸酐酶2抗体碱平衡的作用，协助体内组织排除二氧化碳，碳酸酐酶Ⅱ参与呼吸、钙化、酸碱平衡、骨吸收和各种体液形成的生理过程.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid