组蛋白乙酰转移酶KAT7抗体
规格：1mg/1ml
英文名： KAT7
别名： KAT7_HUMAN; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2.
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KAT7
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
组蛋白乙酰转移酶KAT7抗体产品介绍：background: In the cell, transcription is regulated in part by the histone modification of chromatin. Specifically, histone acetyltransferase proteins and their associated complexes function with co-activators to regulate transcription. One family of histone acetyltransferases is the MYST family of transcriptional silencers, which is linked to ORC (origin recognition complex) function. The ORC is an initiator protein for DNA replication and mediates the acetylation of chromatin to control both DNA replication and gene expression. HBO1 (histone acetyltransferase binding to ORC) is a MYST family protein that interacts with ORC1, the largest subunit of the human ORC complex. HBO1 is a nuclear protein that is highly expressed in human testis. In addition to binding ORC, HBO1 represses AR组蛋白乙酰转移酶KAT7抗体 (androgen receptor)-mediated transcription by binding AR through its N-terminal transcriptional repression domain. HBO1 may play a role in regulating AR-dependent gene transcription in normal and prostate cancer cells. Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses 组蛋白乙酰转移酶KAT7抗体AR-mediated transcription. Subcellular Location: Nucleus; nucleoplasm. Tissue Specificity: Ubiquitously expressed, with highest levels in testis. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the MYST (SAS/MOZ) family. Contains 1 C2HC-type zinc finger. Gene ID: 11143 Database links: Entrez Gene: 11143 Human Entrez Gene: 217127 Mouse Entrez Gene: 303470 Rat Omim: 609880 Human SwissProt: O95251 Human SwissProt: Q5SVQ0 Mouse SwissProt: Q810T5 Rat Unigene: 21907 Human Unigene: 90213 Mouse Unigene: 12618 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白乙酰转移酶KAT7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid