NK细胞抑制性受体2DS3抗体
规格：1mg/1ml
英文名： KIR2DS3
别名： KI2S3_HUMAN; Killer cell immunoglobulin-like receptor 2DS3; KIR2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7; NKAT-7; NKAT7.
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIR2DS3
交叉反应：Human,
细胞定位：细胞膜
NK细胞抑制性受体2DS3抗体产品介绍：background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), NK细胞抑制性受体2DS3抗体while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Subcellular Location: Cell membrane. Similarity: Belongs to the immunoglobulin NK细胞抑制性受体2DS3抗体superfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 3808 Database links: Entrez Gene: 3808 Human Omim: 604954 Human SwissProt: Q14952 Human Unigene: 512572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NK细胞抑制性受体2DS3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 自然杀伤细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid