驱动蛋白家族成员5C抗体
规格：1mg/1ml
英文名： KIF5C
别名： KIFC5C; FLJ44735; KIAA0531; KIF5C_HUMAN; KIF 5C; KIF5C; KIF5C protein; Kinesin family member 5C; Kinesin heavy chain neuron specific 2; Kinesin heavy chain neuron specific; Kinesin5C; KINN; MGC111478;
分子量： 109kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIF5C
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：
驱动蛋白家族成员5C抗体产品介绍：background: Neuronal kinesin heavy chain 2 (NKHC2) is a 1,032 amino acid protein that is part of the kinesin superfamily which consists of the heavy chains of conventional kinesin. NKHC is expressed throughout the central nervous system, but is highly expressed in certain subsets of neurons. NKHC has a unique C-terminal stretch of 69 amino acids and interacts with dystrobrevin, an adaptor/scaffolding protein. This interaction may play a role in the transport and targeting of components of the dystrophin-associated protein complex to precice sites in the cell. NKHC may also be involved in the microtubule-dependent slow axonal transport of neurofilament proteins during the maturation of neuronal cells. Function: Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Subunit: Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1驱动蛋白家族成员5C抗体 and KLC3 (By similarity). Interacts with TRAK1. Subcellular Location: Cytoplasm, cytoskeleton Tissue Specificity: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary. DISEASE: Cortical dysplasia, complex, with other brain malformations 2 (CDCBM2) [MIM:615282]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical驱动蛋白家族成员5C抗体 features include intrauterine growth retardation, fetal akinesia, seizures, microcephaly, lack of psychomotor development, and arthrogryposis. Brain imaging shows malformations of cortical development, including polymicrogyria, gyral simplification, and thin corpus callosum. {ECO:0000269|PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. Contains 1 kinesin motor domain. Gene ID: 94118 Database links: Entrez Gene: 94118 Mouse SwissProt: Q9JKY8 Mouse Unigene: 539078 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
驱动蛋白家族成员5C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid