纤溶酶原激活物抑制因子抗体
规格：1mg/1ml
英文名： PAI1
别名： Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serine (or cysteine) prot
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PAI-1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：分泌型蛋白
纤溶酶原激活物抑制因子抗体产品介绍：background: PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder. Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. Subunit: Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Subcellular Location: Secreted Tissue Specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells Post-translational modifications: Inactivated by proteolytic attack of the urokinase-type纤溶酶原激活物抑制因子抗体 (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. DISEASE: Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. Note=The disease is caused by mutations affecting the gene represented in this entry. Note=High concentrations 纤溶酶原激活物抑制因子抗体of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. Similarity: Belongs to the serpin family Gene ID: 5054 Database links: Entrez Gene: 5054 Human Entrez Gene: 18787 Mouse Entrez Gene: 396945 Pig Entrez Gene: 24617 Rat Omim: 173360 Human SwissProt: P13909 Cow SwissProt: P05121 Human SwissProt: P22777 Mouse SwissProt: P79335 Pig SwissProt: P20961 Rat Unigene: 414795 Human Unigene: 713079 Human Unigene: 250422 Mouse Unigene: 29367 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PAI-1是一种单链糖蛋白，其生理作用很多： （1）与组织型纤溶酶原激活物（tissue plasminogen activator，t-PA）形成1：1的复合物而使t-PA失活; （2）?；せ啄げ槐谎丛吹拿杆到? （3）?；は赴涞慕哟ッ娑肿橹峁沟耐暾? （4）在结缔组织演变、凝血、纤溶、补体激活和炎症反应等过程中具有抑制蛋白降解作用; （5）在细胞周期中，PAI-1转录水平的变化及其在细胞内的积聚，对细胞形态的维持、细胞与其间质的粘附、细胞增殖、信号转导及基因表达等都有重要意义;
纤溶酶原激活物抑制因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid