KIAA1737蛋白抗体
规格：1mg/1ml
英文名： KIAA1737
别名： K1737_HUMAN; KIAA1737; Uncharacterized protein KIAA1737.
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KIAA1737
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：
KIAA1737蛋白抗体产品介绍：background: KIAA1737 is a 399 amino acid protein that is encoded by a gene that maps to human chromosome 14q24.3. Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder α1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on KIAA1737蛋白抗体chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. Function: Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK (By similarity). Subunit: Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Subcellular Location: Nucleus {ECO:0000250}.KIAA1737蛋白抗体 Note=Co-localizes with CLOCK in the nucleus Gene ID: 85457 Database links: Entrez Gene: 85457 Human SwissProt: Q9C0C6 Human SwissProt: Q8R0W1 Mouse Unigene: 709066 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
KIAA1737蛋白抗体研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid