KDELR2蛋白抗体
规格：1mg/1ml
英文名： KDELR2
别名： Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; ELP 1; ELP-1; ELP1; ER lumen protein retaining receptor 2; ERD 2 like protein; ERD2 like protein 1; ERD2-like protein 1; ERD2.2; ER
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KDELR2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：
KDELR2蛋白抗体产品介绍：background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeqKDELR2蛋白抗体, Jul 2008] Function: Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the ERD2 family. Gene ID: 11014 Database links: Entrez Gene: 11014 Human Entrez Gene: KDELR2蛋白抗体66913 Mouse Entrez Gene: 304290 Rat Omim: 609024 Human SwissProt: P33947 Human SwissProt: Q9CQM2 Mouse SwissProt: Q5U305 Rat Unigene: 654552 Human Unigene: 705873 Human Unigene: 181880 Mouse Unigene: 4066 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KDELR2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid