KDEL受体抗体
规格：1mg/1ml
英文名： KDEL Receptor
别名： ER lumen protein retaining receptor 1; ERD 2; ERD2; ERD2.1; ERD21_HUMAN; ERD21; HDEL; KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 1; KDEL (Lys-Asp-Glu-Leu) 72 kD endoplasmi
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KDEL Rec
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep, Xenopus laevis
细胞定位：
KDEL受体抗体产品介绍：background: Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. Function: Required for the retention of luminal endoplasmic reticulum resident KDEL受体抗体proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. Subunit: Upon ligand binding the receptor oligomerizes and interacts with components of the transport machinery such as ARFGAP1 and ARF1. Subcellular Location: Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic KDEL受体抗体reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Post-translational modifications: Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function. Similarity: Belongs to the ERD2 family. Gene ID: 10945 Database links: Entrez Gene: 10945 Human Entrez Gene: 618184 Cow Entrez Gene: 68137 Mouse Entrez Gene: 361577 Rat Omim: 131235 Human SwissProt: P33946 Cow SwissProt: P24390 Human SwissProt: Q99JH8 Mouse SwissProt: Q569A6 Rat Unigene: 515515 Human Unigene: 298433 Mouse Unigene: 1819 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KDEL受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid