钙激活钾通道蛋白β2抗体
规格：1mg/1ml
英文名： KCNMB2
别名： 2700049B16Rik; 3110031N04Rik; BK channel subunit beta 2; BK channel subunit beta-2; BKbeta2; Calcium activated potassium channel subfamily M subunit beta 2; Calcium activated potassium channel subunit
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNMB2
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
钙激活钾通道蛋白β2抗体产品介绍：background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013] Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1钙激活钾通道蛋白β2抗体 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Subcellular Location: Membrane. Tissue Specificity: Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues. Post-translational modifications: 钙激活钾通道蛋白β2抗体N-glycosylated. Similarity: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. Gene ID: 10242 Database links: Entrez Gene: 10242 Human Entrez Gene: 72413 Mouse Entrez Gene: 294961 Rat Omim: 605214 Human SwissProt: Q9Y691 Human SwissProt: Q9CZM9 Mouse SwissProt: Q811Q0 Rat Unigene: 478368 Human Unigene: 64790 Mouse Unigene: 220612 Rat Unigene: 92476 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙激活钾通道蛋白β2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid