热休克蛋白-20抗体
规格：1mg/1ml
英文名： HSP20
别名： Heat Shock Protein 20; FLJ32389; Heat shock 20 kDa like protein p20; Heat shock protein alpha crystallin related B6; Heat shock protein beta 6; Hspb6; HSPB6_HUMAN.
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSP20
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：
产品介绍：background: Hsp20 is a small heat shock protein related to Hsp25, Hsp27 and may form different hetercomplexes with these proteins. The 热休克蛋白-20抗体specific physiological function of Hsp20 is not yet known. It is distributed ubiquitously in tissues, but is found in higher levels in skeletal, smooth and heart muscle. Under normal conditions, Hsp20 is diffusely distributed in the cytosol, but under heat stress conditions, it translocates to the nucleus. Unlike other heat shock proteins the amount of Hsp20 does not increase after heat shock. The Hsp20 was demonstrated to constitute up to 1.3% of the total cellular protein in vertebrate tissues, especially in muscle, and its expression is related to muscle contraction, specifically in slow-twitch muscle. Hsp20 may form different heterocomplexes with other Hsp's, such as alpha-crystalline and Hsp25.热休克蛋白-20抗体 Phosphorylated form of Hsp20 is proposed to interact with monomeric actin whereas dephosphorylated form binds polymeric actin filaments. In normal conditions Hsp20 is diffusely disturbed in cytosol but under the heat stress it undergoes translocation to membrane fraction. Subunit: Homodimer (By similarity). Subcellular Location: Cytoplasm. Nucleus. Note=Translocates to nuclear foci during heat shock. Post-translational 热休克蛋白-20抗体modifications: The N-terminus is blocked. Similarity: Belongs to the small heat shock protein (HSP20) family. Gene ID: 126393 Database links: Entrez Gene: 126393 Human Entrez Gene: 243912 Mouse Entrez Gene: 192245 Rat SwissProt: O14558 Human SwissProt: Q6NVI3 Human SwissProt: Q5EBG6 Mouse SwissProt: P97541 Rat Unigene: 534538 Human Unigene: 34885 Mouse Unigene: 3201 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. HSPs是细胞受应激原刺激后诱导产生的一组应激蛋白，与肿瘤发生、增殖及分化有关。按其分子量不同可分为多种类型，每组的HSPs的分布及功能有所不同。
热休克蛋白-20抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid