氨肽酶Q抗体
规格：1mg/1ml
英文名： Laeverin/Aminopeptidase Q
别名： Aminopeptidase Q; AMPQ_HUMAN; AP-Q; APQ; Aqpep; CHL2 antigen; FLJ90650; Laeverin; LVRN; MGC125378; MGC125379; RGD1562779.
分子量： 113kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Laeverin
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
氨肽酶Q抗体产品介绍：background: Laeverin is a 990 amino acid member of the peptidase M1 family and contains an HEXXHX18E gluzincin motif and an H(G)AMEN motif. Expressed specifically in placenta on embryo-derived extravillous trophoblasts (EVTs), laeverin localizes to the cell membrane and is a single-pass type II membrane protein. Laeverin binds zinc and functions as a bestatin-sensitive leucine aminopeptidase with a potential role in EVT function. This suggests that laeverin may be involved in human placentation, during which EVTs invade maternal decidua and spiral areteries. More specifically, laeverin may function by regulating the activities of key peptides at the embryo-maternal interface. Laeverin has a broad substrate specificity but exhibits a preference for Leu-4-methylcoumaryl-7-amide. In addition, laeverin can form a homodimer with intermolecular disulfide bond(s). Function: Metalloprotease which may be important for placentation by regulating biological activity of氨肽酶Q抗体 key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. Subcellular Location: Membrane. Tissue Specificity: Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected氨肽酶Q抗体 on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level). Post-translational modifications: N-glycosylated. Similarity: Belongs to the peptidase M1 family. Gene ID: 206338 Database links: Entrez Gene: 206338 Human GenBank: BC045809 Human Omim: 610046 Human SwissProt: Q6Q4G3 Human Unigene: 98288 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氨肽酶Q抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 跨膜蛋白 泛素 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid