钙整合素结合蛋白1抗体
规格：1mg/1ml
英文名： CIB1
别名： Sip2-28; Cibkip; Kip; Prkdcip; CIB1_HUMAN; Calcium and integrin-binding protein 1;CIB;Calcium- and integrin-binding protein;CIBP;Calmyrin;DNA-PKcs-interacting protein;Kinase-interacting protein;KIP;SN
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CIB1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆 细胞膜
钙整合素结合蛋白1抗体产品介绍：background: CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain. Function: May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Subunit: Monomer. Interacts with the heterodimeric integrin alpha-IIb/beta3. Interacts with the protein kinases PLK2/SNK and with the region immediately upstream of the kinase domain of DNA-PK. Interacts with PLK3; leading to inhibit PLK3 kinase 钙整合素结合蛋白1抗体activity. Interacts with PSEN2. Interacts with MYO1C (By similarity). Interacts (via C-terminus) with F8. Interacts with NBR1 (via C-terminus). Interacts with FEZ1 (via C-terminus). Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation. Interacts with IFI6. Interacts with BCL2. Interacts with TAS1R2 (via C-terminus); this interaction is independent of the myristoylation state of CIB1. Interacts with ITPR3; in a calcium dependent manner. Interacts with PTK2/FAK1. Interacts with MAP3K5; inhibiting MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2. Subcellular Location: Membrane. Cytoplasm. Nucleus. 钙整合素结合蛋白1抗体Cell projection, filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Tissue Specificity: Ubiquitous. Similarity: Contains 2 EF-hand domains. Gene ID: 10519 Database links: Entrez Gene: 10519 Human Omim: 602293 Human SwissProt: Q99828 Human Unigene: 715556 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CIB1是通过抑制eurekalert AK1（p21蛋白激酶）来发挥作用的。当CIB1激活PAK1后，会促发一系列蛋白磷酸化，从而抑制细胞迁移。CIB1在抑制肿瘤转移中有很重要的作用。
钙整合素结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转运蛋白 细胞粘附分子 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid