KPNA6蛋白抗体
规格：1mg/1ml
英文名： KPNA6
别名： FLJ11249; IMA7_HUMAN; Importin alpha 7 subunit; Importin alpha S2; Importin subunit alpha 7; Importin subunit alpha-7; IPOA 7; IPOA7; Karyopherin alpha 6; Karyopherin alpha 6 (importin alpha 7); Karyo
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KPNA6
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
细胞定位：
产品介绍：background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in KPNA6蛋白抗体the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008] Function: Functions in nuclear protein import as an adapter protein for nuclear KPNA6蛋白抗体receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Subunit: Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1. Tissue Specificity: Widely KPNA6蛋白抗体expressed. Similarity: Belongs to the importin alpha family. Contains 10 ARM repeats. Contains 1 IBB domain. Gene ID: 23633 Database links: Entrez Gene: 23633 Human Entrez Gene: 16650 Mouse Entrez Gene: 362607 Rat Omim: 610563 Human SwissProt: Q0V7M0 Cow SwissProt: O60684 Human SwissProt: O35345 Mouse Unigene: 470588 Human Unigene: 711019 Human Unigene: 202358 Mouse Unigene: 139167 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KPNA6蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid