KPNA3蛋白抗体
规格：1mg/1ml
英文名： KPNA3
别名： SRP1 gamma; hSRP1; IMA3_HUMAN; Importin alpha 3; Importin alpha 3 subunit; Importin alpha 4; Importin alpha Q2; Importin subunit alpha-3; IPOA4; Karyopherin alpha 3; Karyopherin alpha 3 importin alpha
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KPNA3
交叉反应：Human, Mouse, Rhesus monkey
细胞定位：细胞核 细胞浆
KPNA3蛋白抗体产品介绍：background: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009] Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds toKPNA3蛋白抗体 importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Highest levels in heart and skeletal muscle. Similarity: Belongs to the importin alpha family. Contains 10 KPNA3蛋白抗体ARM repeats. Contains 1 IBB domain. Gene ID: 3839 Database links: Entrez Gene: 3839 Human Entrez Gene: 418870 Chicken Entrez Gene: 540719 Cow Entrez Gene: 16648 Mouse Entrez Gene: 396715 Pig Entrez Gene: 361055 Rat Entrez Gene: 706925 Rhesus monkey Omim: 601892 Human SwissProt: O00505 Human SwissProt: O35344 Mouse Unigene: 527919 Human Unigene: 25548 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KPNA3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid