组蛋白H4 K20甲基转移酶抗体
规格：1mg/1ml
英文名： KMT5A
别名： H4 K20 HMTase; H4 K20 specific histone methyltransferase; H4-K20-HMTase SETD8; Histone H4 K20 methyltransferase; Histone lysine N methyltransferase H4 lysine 20 specific; Histone-lysine N-methyltransf
分子量： 43kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KMT5A
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
组蛋白H4 K20甲基转移酶抗体产品介绍：background: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. 组蛋白H4 K20甲基转移酶抗体Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Subcellular Location: Nucleus. Chromosome. Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin. Similarity: Belongs to the histone-lysine methyltransferase family. PR/SET subfamily. Contains 1 SET domain. Gene组蛋白H4 K20甲基转移酶抗体 ID: 387893 Database links: Entrez Gene: 387893 Human Entrez Gene: 67956 Mouse Entrez Gene: 689820 Rat Omim: 607240 Human SwissProt: Q9NQR1 Human SwissProt: Q2YDW7 Mouse Unigene: 443735 Human Unigene: 572262 Human Unigene: 137966 Mouse Unigene: 8879 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组蛋白H4 K20甲基转移酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid