环指蛋白88抗体
规格：1mg/1ml
英文名： TRIM5 delta
别名： EG667823; Gm8833; RING finger protein 88; RNF88; TRIM5; Tripartite motif containing 5 transcript variant iota; Tripartite motif containing 5 transcript variant kappa; Tripartite motif containing prote
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRIM5 de
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
环指蛋白88抗体产品介绍：background: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, all of which lack a B-box type 1 domain, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Additional domains C-terminal to the CC region are variably present. Expression of TRIM5 variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing 环指蛋白88抗体efficiencies. The TRIM5 delta isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5 delta also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner. Subcellular Location:环指蛋白88抗体 Cytoplasmic bodies. Database links: Entrez Gene: 85363 Human Entrez Gene: 319236 Mouse Entrez Gene: 308906 Rat Omim: 608487 Human SwissProt: Q9C035 Human Unigene: 370515 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白88抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 环指蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid