干扰素调节因子8抗体
规格：1mg/1ml
英文名： IRF8
别名： H ICSBP; H-ICSBP; HGNC:5358; HICSBP; ICSBP 1; ICSBP; ICSBP1; Interferon consensus sequence binding protein 1; Interferon consensus sequence binding protein; Interferon consensus sequence-binding prote
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IRF8
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
干扰素调节因子8抗体产品介绍：background: Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008] Function: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative干扰素调节因子8抗体 regulatory role in cells of the immune system. Subcellular Location: Nucleus. Tissue Specificity: Predominantly in lymphoid tissues. Post-translational modifications: Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes. Similarity: Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain. Gene ID: 3394 Database links: Entrez Gene: 3394 Human Entrez Gene: 396385 Chicken Entrez Gene: 454294 干扰素调节因子8抗体Chimpanzee Entrez Gene: 100770390 Chinese Hamster Entrez Gene: 614909 Cow Entrez Gene: 489673 Dog Entrez Gene: 101152979 Gorilla Entrez Gene: 15900 Mouse Entrez Gene: 100173775 Orangutan Entrez Gene: 396645 Pig Entrez Gene: 100350620 Rabbit Entrez Gene: 292060 Rat Entrez Gene: 693933 Rhesus monkey Omim: 601565 Human SwissProt: Q90871 Chicken SwissProt: Q02556 Human SwissProt: P23611 Mouse Unigene: 137427 Human Unigene: 334861 Mouse Unigene: 228738 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
干扰素调节因子8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid