白细胞介素1受体相关蛋白激酶M抗体
规格：1mg/1ml
英文名： IRAKM
别名： ASRT5; IL 1 receptor associated kinase M; IL-1 receptor-associated kinase M; IL1 receptor associated kinase M; Interleukin 1 Receptor Associated Kinase 3; Interleukin 1 Receptor Associated Kinase 3; I
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IRAKM
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞浆
白细胞介素1受体相关蛋白激酶M抗体产品介绍：background: This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] Function: Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 白细胞介素1受体相关蛋白激酶M抗体or stabilizing the receptor complex. Tissue Specificity: Expressed predominantly in peripheral blood lymphocytes. DISEASE: Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.白细胞介素1受体相关蛋白激酶M抗体 Contains 1 death domain. Contains 1 protein kinase domain. Gene ID: 11213 Database links: Entrez Gene: 11213 Human Entrez Gene: 73914 Mouse Entrez Gene: 314870 Rat Omim: 604459 Human SwissProt: Q9Y616 Human SwissProt: Q8K4B2 Mouse Unigene: 369265 Human Unigene: 146194 Mouse Unigene: 147737 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素1受体相关蛋白激酶M抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid