NPHP5蛋白抗体
规格：1mg/1ml
英文名： Nephrocystin 5
别名： IQ motif containing B1; IQ calmodulin binding motif containing protein 1; IQCB1; Nephrocystin 5; NPHP5; IQCB1_HUMAN; Nephrocystin-5 Nephrocystin5.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nephrocy
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit,
细胞定位：
NPHP5蛋白抗体产品介绍：background: This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] Function: Interacts with calmodulin. Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:NPHP5蛋白抗体21565611}. Note=Localization to the centrosome depends on the interaction with CEP290. Tissue Specificity: Ubiquitously expressed in fetal and ***** tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors. {ECO:0000269|PubMed:15723066, ECO:0000269|PubMed:16322217}. DISEASE: NPHP5蛋白抗体Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Note=Localization to the centrosome depends on the interaction with CEP290. Similarity: Contains 4 IQ domains. Gene ID: 9657 Database links: Entrez Gene: 9657 Human Omim: 609237 Human SwissProt: Q15051 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
NPHP5蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid