INT11蛋白抗体
规格：1mg/1ml
英文名： INT11/CPSF3L
别名： 2410006F12Rik; AU044035; Cleavage and polyadenylation specific factor 3 like; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3 like protein; CPSF3-like protein; CPSF3L; CPSF73L; FLJ1
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human INT11/CP
交叉反应：Human, Mouse, Rat, Horse, Zebrafish, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant
细胞定位：细胞核 细胞浆
INT11蛋白抗体产品介绍：background: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] Function: Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the INT11蛋白抗体C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. Similarity: Belongs INT11蛋白抗体to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily. {ECO:0000305}. Gene ID: 54973 Database links: Entrez Gene: 54973 Human Entrez Gene: 71957 Mouse Omim: 611354 Human SwissProt: Q5TA45 Human SwissProt: Q9CWS4 Mouse Unigene: 6449 Human Unigene: 475640 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
INT11蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid