胰岛素瘤相关蛋白2抗体
规格：1mg/1ml
英文名： INSM2
别名： IA 6; IA6; INSM2_HUMAN; Insulinoma associated 2; Insulinoma associated protein 2; mlt1; Zinc finger protein IA 6; Zinc finger protein IA6.
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human INSM2
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞核
胰岛素瘤相关蛋白2抗体产品介绍：background: INSM2 is a 566 amino acid nuclear protein. INSM2 is believed to act as a growth or tumor suppressor in certain neurons and in liver cells. INSM2 contains five zinc finger C2H2-type domains which bind nucleic acids. Zinc fingers are composed of 25-30 amino acid residues and have the ability to bind about five nucleotides. C2H2-type zinc fingers have two cysteines on one extremity of the domain, and two histidines on the other extremity. These four cysteines and histidines interact with one zinc atom, resulting in the finger-like conformation of the domain. It is believed that the C2H2-type zinc fingers require the binding of a zinc atom in order for the finger to bind DNA or RNA. Function: INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. Subcellular Location: 胰岛素瘤相关蛋白2抗体Nuclear Tissue Specificity: Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level). {ECO:0000269|PubMed:21343251}. Similarity:胰岛素瘤相关蛋白2抗体 Contains 5 C2H2-type zinc fingers. Gene ID: 84684 Database links: Entrez Gene: 84684 Human Entrez Gene: 56856 Mouse Entrez Gene: 314131 Rat SwissProt: Q96T92 Human SwissProt: Q9JMC2 Mouse Unigene: 62813 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰岛素瘤相关蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 转录调节因子 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid