聚磷酸肌醇磷酸酶5B抗体
规格：1mg/1ml
英文名： INPP5B
别名： 5-trisphosphate 5-phosphatase; 5PTase; 75 kDa inositol polyphosphate 5 phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; 75kDa; EC 3.1.3.36; I5P2_HUMAN; Inositol polyphosphate 5-phosphatase II
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human INPP5B
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：
聚磷酸肌醇磷酸酶5B抗体产品介绍：background: Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] Function: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269|PubMed:7721860}. Subunit: Interacts with APPL1, FAM109A and FAM109B. Interacts聚磷酸肌醇磷酸酶5B抗体 with several Rab GTPases, at least RAB1A, RAB2A, RAB5A, RAB6A, RAB8A, RAB9A and RAB33B; these interactions may play a dual role in targeting INPP5B to the specific membranes and stimulating the phosphatase activity. {ECO:0000269|PubMed:17956944, ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21233288, ECO:0000269|Ref.10}. Subcellular Location: Cytoplasm, cytosol. Endoplasmic reticulum-Golgi intermediate compartment. Early endosome membrane. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Golgi apparatus. Tissue Specificity: Platelets. Post-translational modifications:聚磷酸肌醇磷酸酶5B抗体 Isoprenylation at Cys-990 may be required for localization at the membrane. {ECO:0000269|PubMed:7721860}. May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form. {ECO:0000269|PubMed:1718960}. Similarity: Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family. Contains 1 Rho-GAP domain. Gene ID: 3633 Database links: Entrez Gene: 3633 Human Entrez Gene: 16330 Mouse Entrez Gene: 362590 Rat Omim: 147264 Human SwissProt: P32019 Human SwissProt: O54996 Mouse Unigene: 449942 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
聚磷酸肌醇磷酸酶5B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid