聚磷酸肌醇磷酸酶4A抗体
规格：1mg/1ml
英文名： INPP4A
别名： Type I 4-phosphatase; 107kDa; 4-bisphosphate 4-phosphatase; 9630012D15; D130048C09Rik; Inositol polyphosphate 4 phosphatase type I 107kDa; Inositol polyphosphate 4 phosphatase type I; Inositol polypho
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human INPP4A
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Xenopus laevis
细胞定位：
聚磷酸肌醇磷酸酶4A抗体产品介绍：background: The inositol polyphosphate 4-phosphatases selectively remove the phosphate from the 4-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Both the type I and type II 4-phosphatases catalyze the hydrolysis of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Type I and type II 4-phosphatases are both alternatively spliced into two isoforms, a and b, which have been detected in human platelets, rat brain, heart, skeletal muscle and spleen; and all isoforms contain a conserved motif CKSAKDRT, which contains the active site consensus sequence聚磷酸肌醇磷酸酶4A抗体 C-X5-R. Both type I and II 4-phosphatases are thought to regulate the level of intracellular calcium by acting as signal terminating enzymes. Function: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate. Tissue Specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. Similarity: Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain. Gene ID: 3631 Database links: Entrez Gene: 3631 Human Entrez Gene: 269180 Mouse Entrez Gene: 100233232 Pig Entrez Gene: 80849 Rat Entrez Gene: 734645 Xenopus laevis聚磷酸肌醇磷酸酶4A抗体 Omim: 600916 Human SwissProt: Q96PE3 Human SwissProt: Q9EPW0 Mouse SwissProt: Q62784 Rat Unigene: 469386 Human Unigene: 5294 Mouse Unigene: 11215 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
聚磷酸肌醇磷酸酶4A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid