A型流感病毒PB1抗体
规格：1mg/1ml
英文名： Influenza A PB1
别名： PB1; PB1-F2 protein; PB1F2_I07A0; Protein PB1-F2.
分子量： 6.6kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Influenza A In
交叉反应：Influenza A
细胞定位：
A型流感病毒PB1抗体产品介绍：Function: Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. May also act in trans: extracellular PB1-F2 released by infected cells could potentially inactivate hosts cell recruitment to the site of infection. During early A型流感病毒PB1抗体stage of infection, may predispose the mitochondria to permeability transition through interaction with human SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis (By similarity). Subunit: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1 (By similarity).A型流感病毒PB1抗体 Subcellular Location: Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most cells types. Otherwise is detected in the nucleus and cytosol (By similarity). Similarity: Belongs to the influenza viruses PB1-F2 family. Gene ID: 3802042 Database links: Entrez Gene: 3802042 Influenza A SwissProt: P0C0U1 Influenza A Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
A型流感病毒PB1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**及病毒
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid